氙氯准分子激光诱导动脉壁荧光的光谱-时间研究。

Spectro-temporal studies of Xe-Cl excimer laser-induced arterial wall fluorescence.

作者信息

Stavridi M, Marmarelis V Z, Grundfest W S

机构信息

University of Southern California, Department of Biomedical Engineering, Los Angeles 90089-1451, USA.

出版信息

Med Eng Phys. 1995 Dec;17(8):595-601. doi: 10.1016/1350-4533(95)00016-g.

DOI:10.1016/1350-4533(95)00016-g

PMID:8564154

Abstract

We report on spectro-temporal fluorescence studies of cadaver femoral arterial walls at different stages in the progression of atherosclerosis. After excitation with a Xe-Cl excimer pulse, the time course of the fluorescence spectrum was recorded over time, and time-resolved multispectral analysis was performed. Then, under the assumption of linearity, we derived a linear spectro-temporal kernel (a weighting function) which describes the temporal behavior of the fluorescence process independently of the pulse width of the photoexcitation. The data analysis revealed both static and dynamic fluorescence characteristics which exhibited a good correlation with histological findings.

摘要

我们报告了对动脉粥样硬化进展不同阶段的尸体股动脉壁进行的光谱-时间荧光研究。用Xe-Cl准分子脉冲激发后，随时间记录荧光光谱的时间进程，并进行时间分辨多光谱分析。然后，在线性假设下，我们推导了一个线性光谱-时间核（一种加权函数），它描述了荧光过程的时间行为，与光激发的脉冲宽度无关。数据分析揭示了静态和动态荧光特征，这些特征与组织学结果显示出良好的相关性。