Rabin E Z, Weinberger V, Tattrie B
Can J Neurol Sci. 1977 May;4(2):125-30.
The ribonuclease activity of cerebrospinal fluid of 219 patients was studied. The normal level was 269 +/- 95 units/ml. Consistent elevations above 550 units/ml were found in: 1. Chronic cerebrovascular disease; 2. Spinal cord compression; 3. Tumors. The molecular weights of the ribonucleases in the cerebrospinal fluid are approximately 33,000; 21,000 and 15,000; the major species is the one with m.w. 33,000. Although the increase in the CSF ribonuclease activity is not disease specific, the measurement has provided corroborative help in cases when the CSF protein is normal. The increase in CSF RNAase is not due to red or white blood cells and the immunologic data suggest that the CSF enzyme activity is derived from the blood stream. Further studies are necessary to rule out a nerve cell origin of the CSF ribonuclease activity.
对219例患者脑脊液的核糖核酸酶活性进行了研究。正常水平为269±95单位/毫升。在以下情况中发现一致高于550单位/毫升的升高：1. 慢性脑血管疾病；2. 脊髓压迫；3. 肿瘤。脑脊液中核糖核酸酶的分子量约为33,000、21,000和15,000；主要种类是分子量为33,000的那种。虽然脑脊液核糖核酸酶活性的升高并非疾病特异性的，但在脑脊液蛋白正常的情况下，该测量提供了佐证。脑脊液核糖核酸酶的升高并非由于红细胞或白细胞，免疫数据表明脑脊液酶活性源自血流。需要进一步研究以排除脑脊液核糖核酸酶活性的神经细胞起源。
