The antitumoral compound Kahalalide F acts on cell lysosomes.
作者信息
García-Rocha M, Bonay P, Avila J
机构信息
Centro de Biología Molecular, Universidad Autónoma de Madrid, Spain.
出版信息
Cancer Lett. 1996 Jan 19;99(1):43-50. doi: 10.1016/0304-3835(95)04036-6.
PMID:8564928
Abstract
The target for the antitumoral peptidic drug, Kahalalide F, has been studied in cultured cells. In the presence of the compound, the cells became impressively swollen, showing the formation of large vacuoles. The formation of these vacuoles appears to be the consequence of changes in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.
摘要
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