García-Rocha M, Bonay P, Avila J
Centro de Biología Molecular, Universidad Autónoma de Madrid, Spain.
Cancer Lett. 1996 Jan 19;99(1):43-50. doi: 10.1016/0304-3835(95)04036-6.
The target for the antitumoral peptidic drug, Kahalalide F, has been studied in cultured cells. In the presence of the compound, the cells became impressively swollen, showing the formation of large vacuoles. The formation of these vacuoles appears to be the consequence of changes in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.
