Fidel P L, Cutright J L, Tait L, Sobel J D
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA.
J Infect Dis. 1996 Feb;173(2):425-31. doi: 10.1093/infdis/173.2.425.
Vaginal Candida glabrata infections have increased significantly in recent years and are particularly common in women with uncontrolled diabetes mellitus. Efforts to understand the pathogenesis and treatment of this infection have been hindered by the lack of experimental animal models. Before onset of hyperglycemia, nonobese diabetic (NOD) mice inoculated intravaginally with clinical C. glabrata isolates were shown to support high vaginal titers of C. glabrata for > 14 days with evidence for superficial invasion of vaginal epithelial tissue. In contrast, congenic diabetic-resistant mice and mice susceptible to Candida albicans infections were significantly less susceptible to vaginal infection by C. glabrata, suggesting a potential link between the susceptibility of NOD mice to diabetes and their susceptibility to vaginal C. glabrata infections. This animal model of C. glabrata vaginitis provides a means to study the genetics and pathogenesis of C. glabrata infections and to evaluate the efficacy of antimycotic agents against C. glabrata.
近年来，阴道光滑念珠菌感染显著增加，在糖尿病控制不佳的女性中尤为常见。由于缺乏实验动物模型，对这种感染的发病机制和治疗方法的研究受到了阻碍。在高血糖症发作之前，经阴道接种临床光滑念珠菌分离株的非肥胖糖尿病（NOD）小鼠被证明能够在阴道中维持较高滴度的光滑念珠菌超过14天，并有证据表明阴道上皮组织存在浅表侵袭。相比之下，同基因糖尿病抗性小鼠和易患白色念珠菌感染的小鼠对光滑念珠菌阴道感染的易感性明显较低，这表明NOD小鼠对糖尿病的易感性与其对阴道光滑念珠菌感染的易感性之间可能存在联系。这种光滑念珠菌性阴道炎动物模型为研究光滑念珠菌感染的遗传学和发病机制以及评估抗真菌药物对光滑念珠菌的疗效提供了一种手段。
