Wai S N, Takade A, Amako K
Department of Bacteriology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Microbiol Immunol. 1995;39(7):451-6. doi: 10.1111/j.1348-0421.1995.tb02228.x.
The clinically isolated heat labile enterotoxin (LT)-producing strains of Escherichia coli can be separated into two groups, namely spontaneous LT-releasing strain and non-spontaneous LT-releasing strain, based on their phenotypes of spontaneous release of LT into the culture medium. The phenotype of spontaneous LT release was observed to correlate closely with the phenotype of the release of numerous small vesicles into the culture medium. Both morphological and biological examinations of the vesicle showed that the vesicle was released from the outer membrane. It can, therefore, be assumed that LT may be released from the cell at the time the vesicles form.
临床上分离出的产热不稳定肠毒素（LT）的大肠杆菌菌株，根据其将LT自发释放到培养基中的表型，可分为两组，即自发LT释放菌株和非自发LT释放菌株。观察到LT的自发释放表型与向培养基中释放大量小泡的表型密切相关。对小泡的形态学和生物学检查均表明，小泡是从外膜释放出来的。因此，可以推测LT可能在小泡形成时从细胞中释放出来。
