暴露于高密度50赫兹磁场会增加次黄嘌呤-鸟嘌呤磷酸核糖基转移酶基因突变。

Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to high-density 50-Hz magnetic fields.

作者信息

Miyakoshi J, Yamagishi N, Ohtsu S, Mohri K, Takebe H

机构信息

Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan.

出版信息

Mutat Res. 1996 Jan 17;349(1):109-14. doi: 10.1016/0027-5107(95)00166-2.

DOI:10.1016/0027-5107(95)00166-2

PMID:8569782

Abstract

Exposure to extremely low frequency magnetic field (ELFMF) of 50 Hz and 400 mT induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene of human melanoma MeWo cells. The mutant frequency was enhanced both by increasing the exposure period and the induced current intensity. Mutations induced by X-rays were enhanced by ELFMF exposure. No significant increase in mutant frequency occurred when DNA replication was inhibited during ELFMF exposure. DNA replication error is suspected of causing the mutations produced by ELFMF exposure.

摘要

暴露于50Hz和400mT的极低频磁场（ELFMF）会诱导人黑素瘤MeWo细胞的次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶基因突变。通过延长暴露时间和增加感应电流强度，突变频率均会提高。ELFMF暴露会增强X射线诱导的突变。在ELFMF暴露期间抑制DNA复制时，突变频率没有显著增加。怀疑DNA复制错误是由ELFMF暴露产生突变的原因。