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Mutation induction by high-density, 50-Hz magnetic fields in human MeWo cells exposed in the DNA synthesis phase.

作者信息

Miyakoshi J, Kitagawa K, Takebe H

机构信息

Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Japan.

出版信息

Int J Radiat Biol. 1997 Jan;71(1):75-9. doi: 10.1080/095530097144445.

DOI:10.1080/095530097144445
PMID:9020966
Abstract

Exposure of cultured human MeWo cells to high-density (400 mT at 50 Hz) extremely low frequency magnetic fields (ELF-MF) induced mutations in the hypoxanthine-guanine phosphoribosyl transferase gene. Mutation induced by the ELF-MF increased during the DNA-synthesis phase in synchronously growing cells. DNA replication errors and/or disturbance of the mismatch repair systems caused by exposure to ELF-MF may be involved in the mutagenic effect.

摘要

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