Horton A W, Bingham E L
J Natl Cancer Inst. 1977 May;58(5):1225-8. doi: 10.1093/jnci/58.5.1225.
Serum properdin levels were determined for 21 benzidine operators at 6-month intervals for 2 years after termination of exposure to this carcinogen. Of this group, 7 developed bladder cancers within a 4-month period prior to the initial assay, and all 7 showed properdin levels below the median for the group as a whole. Two of the 3 workers who had had a brief exposure previously to beta-naphthylamine developed benign bladder tumors but had no malignant neoplasms up to 13 years later. The properdin assays of these 3 men remained consistently at or above the median values. No man developed a bladder tumor who was exposed less than 6 years to benzidine, even though 2 of these men showed low properdin levels. Of the 4 whose properdin levels were initially above the median but dropped below in subsequent assays, 3 developed bladder cancers 0.5, 4, and 9 years later. Only 1 man whose properdin level remained high in 1958-59 developed a bladder cancer 7 years later, and his immunologic picture may have been complicated by recovery from a larynx tumor in 1954. Recurrence of bladder tumors among the original 9 cases has occurred only among the 5 whose properdin levels remained below the median. The 1 whose ranking fell most dramatically (from 13 to 19) has had 13 recurrences in 13 years.
在接触致癌物联苯胺终止后，对21名联苯胺作业工人每隔6个月测定血清备解素水平，持续2年。在这组人群中，7人在首次检测前4个月内患膀胱癌，且这7人的备解素水平均低于整个组的中位数。3名曾短暂接触过β-萘胺的工人中，有2人患良性膀胱肿瘤，但直至13年后均无恶性肿瘤。这3人的备解素检测结果一直保持在中位数或以上。接触联苯胺少于6年的工人中无人患膀胱肿瘤，尽管其中2人备解素水平较低。在4名备解素水平最初高于中位数但在随后检测中降至中位数以下的工人中，有3人分别在0.5年、4年和9年后患膀胱癌。只有1名在1958 - 1959年备解素水平一直较高的工人在7年后患膀胱癌，其免疫情况可能因1954年喉肿瘤康复而变得复杂。最初9例病例中，膀胱肿瘤复发仅发生在5名备解素水平低于中位数的患者中。排名下降最显著（从第13名降至第19名）的1名患者在13年内复发了13次。
