Tsuchiya K, Okubo T, Ishizu S
Br J Ind Med. 1975 Aug;32(3):203-9. doi: 10.1136/oem.32.3.203.
This report studies 100 cases of occupational bladder cancer which were reported between 1949 and 1970 by large companies producing dye. It is estimated that in fact a great many more than 100 cases may have developed during the 56 years from 1914 to 1970, as this period corresponds with the beginning of dye production to the termination of benzidine and beta-naphthylamine manufacture in Japan. New cases of occupational bladder tumour should diminish significantly in the future in Japan on account of the prohibition of the production of beta-naphthylamine and benzidine. However, it is important to follow-up continuously workers who have been exposed to these amines. In Japan no cases of occupational bladder tumours from the rubber industry have been reported. It is emphasized that prospective epidemiological studies are required not only in the rubber industry but also in other industries where amines may constitute an occupational hazard.
本报告研究了1949年至1970年间由大型染料生产公司报告的100例职业性膀胱癌病例。据估计，在1914年至1970年的56年间，实际发生的病例可能远不止100例，因为这一时期与日本染料生产的开始至联苯胺和β-萘胺生产的终止相对应。由于禁止生产β-萘胺和联苯胺，日本未来职业性膀胱肿瘤的新病例应会显著减少。然而，对接触过这些胺类物质的工人进行持续随访很重要。在日本，尚未报告橡胶行业的职业性膀胱肿瘤病例。需要强调的是，不仅在橡胶行业，而且在胺类物质可能构成职业危害的其他行业，都需要进行前瞻性流行病学研究。
