Odeh R M, Cornish L A
Department of Pharmacy Services, University of Michigan Medical Center and College of Pharmacy, Ann Arbor 48109, USA.
Pharmacotherapy. 1995 Sep-Oct;15(5):648-59. doi: 10.1002/j.1875-9114.1995.tb02875.x.
Hypercholesterolemia, cigarette smoking, hypertension, and obesity are known contributing risk factors for the development of atherosclerotic coronary artery disease (CAD). However, they account for only half of all cases of CAD, and the complete pathologic process underlying atherosclerosis remains unknown. Growing evidence suggests that oxidative modification of low-density lipoprotein (LDL) may be of particular importance in the pathogenesis. Oxidized LDL exhibits proatherogenic effects. Therefore, current research has focused on inhibiting the oxidation of LDL as a means of inhibiting the atherosclerotic process. One such approach is to enhance the endogenous antioxidant defense systems within the LDL particle with lipophilic antioxidants such as alpha-tocopherol and beta-carotene, or by supplementing the aqueous-phase antioxidant capacity with ascorbic acid. Observational data suggest a protective effect of antioxidant supplementation on the incidence of CAD; however, specific doses cannot be recommended since the data are inconclusive.
高胆固醇血症、吸烟、高血压和肥胖是已知的导致动脉粥样硬化性冠状动脉疾病（CAD）的危险因素。然而，它们仅占所有CAD病例的一半，动脉粥样硬化的完整病理过程仍不清楚。越来越多的证据表明，低密度脂蛋白（LDL）的氧化修饰在发病机制中可能特别重要。氧化型LDL具有促动脉粥样硬化作用。因此，目前的研究集中在抑制LDL的氧化，作为抑制动脉粥样硬化过程的一种手段。一种方法是用亲脂性抗氧化剂如α-生育酚和β-胡萝卜素增强LDL颗粒内的内源性抗氧化防御系统，或用抗坏血酸补充水相抗氧化能力。观察数据表明抗氧化剂补充对CAD发病率有保护作用；然而，由于数据尚无定论，无法推荐具体剂量。
