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本文引用的文献

1
Peptide nucleic acid (PNA) conformation and polymorphism in PNA-DNA and PNA-RNA hybrids.肽核酸（PNA）在PNA-DNA和PNA-RNA杂交体中的构象与多态性。
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9542-6. doi: 10.1073/pnas.90.20.9542.
2
Sequence specific inhibition of DNA restriction enzyme cleavage by PNA.肽核酸对DNA限制性内切酶切割的序列特异性抑制作用
Nucleic Acids Res. 1993 Jan 25;21(2):197-200. doi: 10.1093/nar/21.2.197.
3
Molecular mechanics calculations of the structures of polyamide nucleic acid DNA duplexes and triple helical hybrids.聚酰胺核酸DNA双链体和三螺旋杂交体结构的分子力学计算。
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7518-22. doi: 10.1073/pnas.90.16.7518.
4
Structural characterization of PNA-DNA duplexes by NMR. Evidence for DNA in a B-like conformation.通过核磁共振对肽核酸-脱氧核糖核酸双链体进行结构表征。脱氧核糖核酸呈类B构象的证据。
Biochemistry. 1994 Aug 23;33(33):9820-5. doi: 10.1021/bi00199a002.
5
NMR structure of d(CGCA3T3GCG)2:tren-microgonotropen-b:Zn(II) complex and solution studies of metal ion complexes of tren-microgonotropen-b interacting with DNA.d(CGCA3T3GCG)2:tren-微促性腺激素-b:Zn(II)复合物的核磁共振结构以及tren-微促性腺激素-b与DNA相互作用的金属离子复合物的溶液研究
Bioorg Med Chem. 1995 Jun;3(6):631-46. doi: 10.1016/0968-0896(95)00051-h.
6
NMR solution structure of a peptide nucleic acid complexed with RNA.与RNA复合的肽核酸的核磁共振溶液结构
Science. 1994 Aug 5;265(5173):777-80. doi: 10.1126/science.7519361.
7
Structure of the B-DNA decamer C-C-A-A-C-G-T-T-G-G and comparison with isomorphous decamers C-C-A-A-G-A-T-T-G-G and C-C-A-G-G-C-C-T-G-G.B型DNA十聚体C-C-A-A-C-G-T-T-G-G的结构及其与同晶型十聚体C-C-A-A-G-A-T-T-G-G和C-C-A-G-G-C-C-T-G-G的比较
J Mol Biol. 1991 Jan 5;217(1):177-99. doi: 10.1016/0022-2836(91)90619-h.
8
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.通过胸腺嘧啶取代的聚酰胺进行链置换对DNA的序列选择性识别
Science. 1991 Dec 6;254(5037):1497-500. doi: 10.1126/science.1962210.
9
AM1-SM2 and PM3-SM3 parameterized SCF solvation models for free energies in aqueous solution.用于水溶液中自由能的AM1-SM2和PM3-SM3参数化自洽场溶剂化模型。
J Comput Aided Mol Des. 1992 Dec;6(6):629-66. doi: 10.1007/BF00126219.
10
Antisense and antigene properties of peptide nucleic acids.肽核酸的反义及反基因特性。
Science. 1992 Nov 27;258(5087):1481-5. doi: 10.1126/science.1279811.

肽核酸-RNA异源双链体中的残基间氢键

Interresidue hydrogen bonding in a peptide nucleic acid.RNA heteroduplex.

作者信息

Torres R A, Bruce T C

机构信息

Department of Chemistry, University of California, Santa Barbara 93106, USA.

出版信息

Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):649-53. doi: 10.1073/pnas.93.2.649.

DOI:10.1073/pnas.93.2.649
PMID:8570609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC40106/
Abstract

Previous molecular mechanics calculations suggest that strands of peptide nucleic acids (PNAs) and complementary oligonucleotides form antiparallel duplexes stabilized by interresidue hydrogen bonds. In the computed structures, the amide carbonyl oxygen nearest the nucleobase (O7') forms an interresidue hydrogen bond with the backbone amide proton of the following residue, (n + 1)H1'. Of the 10 published two dimensional 1H NMR structures of a hexameric PNA.RNA heteroduplex. PNA(GAACTC).r(GAGUUC), 9 exhibit two to five potential interresidue hydrogen bonds. In our minimized average structure, created from the coordinates of these 10 NMR structures, three of the five possible interresidue hydrogen bond sites within the PNA backbone display the carbonyl oxygen (O7') and the amide proton (n + 1)H1' distances and N1'-H1'-(n - 1)O7' angles optimal for hydrogen bond formation. The finding of these interresidue hydrogen bonds supports the results of our previous molecular mechanics calculations.

摘要

先前的分子力学计算表明，肽核酸（PNA）链与互补寡核苷酸形成由残基间氢键稳定的反平行双链体。在计算结构中，最靠近核碱基的酰胺羰基氧（O7'）与下一个残基的主链酰胺质子（n + 1）H1'形成残基间氢键。在已发表的六聚体PNA.RNA异源双链体PNA(GAACTC).r(GAGUUC)的10个二维1H NMR结构中，9个结构显示出两到五个潜在的残基间氢键。在我们根据这10个NMR结构的坐标创建的最小化平均结构中，PNA主链内五个可能的残基间氢键位点中的三个显示出羰基氧（O7'）和酰胺质子（n + 1）H1'的距离以及N1'-H1'-(n - 1)O7'角度最适合形成氢键。这些残基间氢键的发现支持了我们先前分子力学计算的结果。