Department of Epidemiology, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Nutrients. 2021 Nov 7;13(11):3970. doi: 10.3390/nu13113970.
The Mediterranean diet has been associated with the risk of Parkinson's disease (PD), but limited research has been performed on other dietary patterns. We studied the relationship between overall diet quality and PD risk in the general population. We included 9414 participants from the Rotterdam Study, a prospective population-based study in the Netherlands. Diet was defined using a Dutch diet quality score, a Mediterranean diet score and data-driven dietary patterns constructed with principal component analysis (PCA). During an average follow-up of 14.1 years, PD was diagnosed in 129 participants. We identified a 'Prudent', 'Unhealthy' and 'Traditional Dutch' pattern from the PCA. We found a possible association between the Mediterranean diet (Hazard ratio (HR) per standard deviation (SD) 0.89 (95% confidence interval (CI) 0.74-1.07)), the 'Prudent' pattern (HR per SD 0.81 (95% CI 0.61-1.08)) and the risk of PD. However, no associations with PD risk were found for the Dutch diet quality score (HR per SD 0.93 (95% CI 0.77-1.12)), the 'Unhealthy' pattern (HR per SD 1.05 (95% CI 0.85-1.29)) or the 'Traditional Dutch' pattern (HR per SD 0.90 (95% CI 0.69-1.17)). In conclusion, our results corroborate previous findings of a possible protective effect of the Mediterranean diet. Further research is warranted to study the effect of other dietary patterns on PD risk.
地中海饮食与帕金森病（PD）的风险相关，但对其他饮食模式的研究有限。我们研究了一般人群中整体饮食质量与 PD 风险之间的关系。我们纳入了来自荷兰鹿特丹研究的 9414 名参与者，这是一项前瞻性的基于人群的研究。饮食通过荷兰饮食质量评分、地中海饮食评分和基于主成分分析（PCA）构建的数据驱动饮食模式来定义。在平均 14.1 年的随访期间，129 名参与者被诊断出患有 PD。我们从 PCA 中确定了“谨慎”、“不健康”和“传统荷兰”模式。我们发现地中海饮食（每标准差的危险比（HR）0.89（95%置信区间（CI）0.74-1.07））、“谨慎”模式（每标准差的 HR 0.81（95% CI 0.61-1.08））与 PD 风险之间可能存在关联。然而，对于荷兰饮食质量评分（每标准差的 HR 0.93（95% CI 0.77-1.12））、“不健康”模式（每标准差的 HR 1.05（95% CI 0.85-1.29））或“传统荷兰”模式（每标准差的 HR 0.90（95% CI 0.69-1.17））与 PD 风险均无关联。总之，我们的结果证实了地中海饮食可能具有保护作用的先前发现。需要进一步研究来研究其他饮食模式对 PD 风险的影响。
