Katoh M, Unakami M, Hara M, Fukuchi S
Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
J Gastroenterol. 1995 Oct;30(5):615-8. doi: 10.1007/BF02367787.
The incidence of bone metastasis from colorectal cancer is reported to be 10.7% in autopsy cases. However, the characteristics of the primary cancers, as well as the patterns of bone metastasis, remain unclear. We analyzed the clinical and autopsy records of 118 patients with primary colorectal cancer treated either surgically or conservatively and eventually autopsied between 1970 and 1987 at Toranomon Hospital in Tokyo. Bone metastasis was detected in 23.7% (28/118). The average age of patients with bone metastasis was lower than that in patients without bone metastasis (P < 0.02). Cancers to the rectum and cecum were accompanied by bone metastasis more frequently than cancers of other portions of the colon. Signet-ring cell carcinoma showed a high incidence of bone metastasis (P = 0.041). Bone metastasis from colorectal cancer was associated with liver or lung metastases (P < 0.0001). These results indicated that bone metastasis from colorectal cancer is not as infrequent as previously described.
据报告，在尸检病例中，结直肠癌骨转移的发生率为10.7%。然而，原发性癌症的特征以及骨转移的模式仍不清楚。我们分析了1970年至1987年间在东京虎之门医院接受手术或保守治疗并最终进行尸检的118例原发性结直肠癌患者的临床和尸检记录。骨转移的检出率为23.7%（28/118）。发生骨转移的患者的平均年龄低于未发生骨转移的患者（P < 0.02）。直肠和盲肠的癌症比结肠其他部位的癌症更常伴有骨转移。印戒细胞癌的骨转移发生率较高（P = 0.041）。结直肠癌的骨转移与肝或肺转移相关（P < 0.0001）。这些结果表明，结直肠癌的骨转移并不像之前描述的那样罕见。
