系统性红斑狼疮中DNA抗体水平与临床疾病活动度的相关性。
Correlation between levels of DNA antibodies and clinical disease activity in SLE.
作者信息
Davis P, Percy J S, Russell A S
出版信息
Ann Rheum Dis. 1977 Apr;36(2):157-9. doi: 10.1136/ard.36.2.157.
Abstract
Sera were tested from 23 patients with systemic lupus erythematosus followed over a period of 1 to 5 years. Antibodies to native DNA were measured and correlated retrospectively with clinical evidence of disease activity. The overall degree of correlation between the presence of DNA antibodies and evidence of disease activity was good (P less than 0-001). Of 206 sera tested, only 4 had a normal DNA antibody at a time when significant clinical activity was noted. In contrast, 34 sera had mild to moderately raised DNA antibody levels at times of clinical remission. Although DNA antibodies are a useful investigation in the monitoring of disease activity, changes in therapy should not necessarily be made on DNA antibody levels alone.
摘要
对23例系统性红斑狼疮患者进行了为期1至5年的随访，并检测了他们的血清。检测了针对天然DNA的抗体，并回顾性地将其与疾病活动的临床证据进行关联。DNA抗体的存在与疾病活动证据之间的总体相关性良好（P小于0.001）。在检测的206份血清中，只有4份在出现显著临床活动时DNA抗体正常。相比之下，34份血清在临床缓解期DNA抗体水平轻度至中度升高。虽然DNA抗体在监测疾病活动方面是一项有用的检查，但不应仅根据DNA抗体水平来决定是否改变治疗方案。
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