无效红细胞生成在类风湿关节炎贫血中的作用。
Role of ineffective erythropoiesis in the anaemia of rheumatoid arthritis.
作者信息
Samson D, Halliday D, Gumpel J M
出版信息
Ann Rheum Dis. 1977 Apr;36(2):181-5. doi: 10.1136/ard.36.2.181.
The importance of inadequate haemoglobin synthesis and ineffective erythropoiesis in the anaemia of rheumatoid arthritis was studied by measuring the incorporation of 15N glycine into haemoglobin haem and early labelled bilirubin in a patient with severe anaemia before and after response to gold therapy. Initially, total erythroid haem turnover was decreased but haem turnover due to ineffective erythropoiesis was markedly increased, accounting for 29% of total erythroid haem turnover. Gold therapy resulted in marked clinical improvement, accompanied by a rise in haemoglobin to normal. Total erythroid haem turnover increased and the percentage ineffective erythropoiesis fell to normal. Ineffective erythropoiesis may thus be an important reversible factor in the production of the anaemia of rheumatoid arthritis.
通过测量一位重度贫血患者在接受金疗法前后，15N甘氨酸掺入血红蛋白血红素和早期标记胆红素的情况，研究了血红蛋白合成不足和无效红细胞生成在类风湿关节炎贫血中的重要性。最初，总的红系血红素周转率降低，但由于无效红细胞生成导致的血红素周转率显著增加，占总的红系血红素周转率的29%。金疗法使临床症状显著改善，同时血红蛋白升至正常水平。总的红系血红素周转率增加，无效红细胞生成的百分比降至正常。因此，无效红细胞生成可能是类风湿关节炎贫血产生过程中的一个重要可逆因素。
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