Toimela T, Tähti H, Salminen L
Medical School, University of Tampere, Finland.
Ophthalmic Res. 1995;27 Suppl 1:150-3. doi: 10.1159/000267861.
The retinal pigment epithelium (RPE) removes the outer segments of photoreceptor cells by phagocytosis. We studied the effects of tamoxifen and chloroquine on the activity of the lysosomal enzymes N-acetyl-beta-glucosaminidase and cathepsin D in RPE in vitro to evaluate the possible eye toxicity caused by these drugs. The results show decreases in the activities of lysosomal enzymes after drug exposure. The enzymes tested seemed to be more sensitive to tamoxifen than to chloroquine. A profound decrease in the activities of the lysosomal enzymes only started at concentrations above therapeutic dose levels.
视网膜色素上皮（RPE）通过吞噬作用清除光感受器细胞的外段。我们在体外研究了他莫昔芬和氯喹对RPE中溶酶体酶N-乙酰-β-氨基葡萄糖苷酶和组织蛋白酶D活性的影响，以评估这些药物可能引起的眼毒性。结果显示药物暴露后溶酶体酶活性降低。所测试的酶似乎对他莫昔芬比对氯喹更敏感。溶酶体酶活性的显著降低仅在高于治疗剂量水平的浓度时才开始。
