Bensoula A N, Guastavino J M, Lalonde R, Portet R, Bertin R, Krafft B
Université de Nancy 1, Laboratorie de Biologie et Physiologie du Comportement, URA CNRS 1293, Vandoeuvre-les-Nancy, France.
Physiol Behav. 1995 Nov;58(5):823-5. doi: 10.1016/0031-9384(95)00101-n.
Staggerer mutant mice were compared to normal mice of two different ages (2-6 mo) in two tasks requiring navigational skills in a circular maze visible platform condition and a T-maze. Staggerer mutants had higher latencies than normal mice in both tests. The performance of normal mice worsened with age for both tests. The aging factor interacted with the genotype factor only in the circular maze, where the mutant-nonmutant differential was wider among juvenile animals. In neither task was there evidence of a more pronounced impairment with aging in staggerer mutants. It remains to be determined in this mutant at more advanced stages of aging or in other models of chronic neural disease whether early neuropathology accelerates brain aging.
在两项需要在圆形迷宫可见平台条件和T型迷宫中具备导航技能的任务中，将蹒跚突变小鼠与两种不同年龄（2至6个月）的正常小鼠进行了比较。在两项测试中，蹒跚突变小鼠的潜伏期均比正常小鼠长。两项测试中，正常小鼠的表现均随年龄增长而变差。衰老因素仅在圆形迷宫中与基因型因素相互作用，在幼年动物中，突变体与非突变体之间的差异更大。在这两项任务中，均没有证据表明蹒跚突变小鼠随着年龄增长会出现更明显的损伤。在这种突变体的更晚期衰老阶段或其他慢性神经疾病模型中，早期神经病理学是否会加速脑衰老仍有待确定。
