Fuse H, Akashi T, Fujishiro Y, Kazama T, Katayama T
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Arch Androl. 1995 Sep-Oct;35(2):143-8. doi: 10.3109/01485019508987865.
Sixty patients with varicocele, complaining of infertility, underwent a corrective operation. Eighteen (30%) of the 60 patients impregnated their mates (impregnating group). Sperm concentration significantly increased after the operation in the impregnating group (p < .05), but not in the patients who failed to impregnate their mates (nonimpregnating group). Sperm motility was not altered after the operation in these two groups. Sperm velocity significantly increased postoperatively in the impregnating group (p < .05), while linearity was not altered in either group. Sperm swelling significantly increased postoperatively in the impregnating group (p < .05), but not in the nonimpregnating group. Preoperative sperm parameters were not different between the two groups. Varicocele may disturb sperm function including sperm motion besides spermatogenesis and may impair the fertility potential. However, a prospective large-scale controlled study is required to obtain a definitive conclusion.
60例患有精索静脉曲张且主诉不育的患者接受了矫正手术。60例患者中有18例（30%）使配偶受孕（受孕组）。受孕组术后精子浓度显著升高（p < 0.05），而配偶未受孕的患者（未受孕组）术后精子浓度未升高。两组术后精子活力均未改变。受孕组术后精子速度显著升高（p < 0.05），而两组的直线性均未改变。受孕组术后精子肿胀显著增加（p < 0.05），未受孕组则未增加。两组术前精子参数无差异。精索静脉曲张可能除了干扰精子发生外，还会扰乱包括精子运动在内的精子功能，并可能损害生育潜能。然而，需要进行一项前瞻性大规模对照研究以得出明确结论。
