Falconer A E, Carr R, Edwards S W
Department of Biochemistry and Haematology, University of Liverpool, UK.
Biol Neonate. 1995;68(4):264-9. doi: 10.1159/000244245.
Preterm neonates are vulnerable to infection as a result of a compromised immune system. The function of neutrophils from 'well', 'stressed', and 'maturing' preterm neonates was compared with term neonate and adult neutrophils using a whole-blood phagocytosis assay. Cell surface expression of complement receptors and immunoglobulin G receptors was measured on neutrophils in whole blood from the same samples. Fewer actively phagocytosing neutrophils were found in all preterm neonate samples, especially in maturing neonates. Phagocytic rates were slower, and the number of Escherichia coli ingested was smaller in preterm neonate than in term neonate neutrophils. Expression of immunoglobulin G receptors and complement receptor 3 on neutrophils was not directly related to phagocytic activity.
由于免疫系统受损，早产儿易受感染。使用全血吞噬试验，将“健康”、“应激”和“成熟中”的早产儿中性粒细胞的功能与足月儿及成人的中性粒细胞进行了比较。在相同样本的全血中，对中性粒细胞上补体受体和免疫球蛋白G受体的细胞表面表达进行了检测。在所有早产儿样本中，尤其是成熟中的新生儿，发现积极吞噬的中性粒细胞较少。早产儿中性粒细胞的吞噬速率较慢，摄入的大肠杆菌数量比足月儿中性粒细胞少。中性粒细胞上免疫球蛋白G受体和补体受体3的表达与吞噬活性无直接关系。
