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DL-乙硫氨酸和四氯化碳损伤后大鼠甲胎蛋白生物合成增加。

Increased alpha-fetoprotein biosynthesis in rats following DL-ethionine and carbon tetrachloride injuries.

作者信息

Watanabe A

出版信息

Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):163-6.

PMID:65785
Abstract

The incorporation of 14C-leucine into alpha-fetoprotein (AFP) in serum and liver extracts from DL-ethionine and carbon tetrachloride (CCl4)-injured rats was measured directly by using an immunochemical technique. The maximum value with nearly 10-fold increases of serum AFP was obtained in 3 days of both treatments. However, no significant increase in the immunoprecipitable AFP in liver extracts was detected under these conditions.

摘要

采用免疫化学技术直接测定了DL-乙硫氨酸和四氯化碳(CCl4)损伤大鼠血清及肝脏提取物中14C-亮氨酸掺入甲胎蛋白(AFP)的情况。两种处理在3天时均获得了血清AFP近10倍增加的最大值。然而,在这些条件下未检测到肝脏提取物中可免疫沉淀的AFP有显著增加。

相似文献

1
Increased alpha-fetoprotein biosynthesis in rats following DL-ethionine and carbon tetrachloride injuries.DL-乙硫氨酸和四氯化碳损伤后大鼠甲胎蛋白生物合成增加。
Res Commun Chem Pathol Pharmacol. 1977 Jan;16(1):163-6.
2
Differential mechanisms of increased alpha 1-fetoprotein production in rats following carbon tetrachloride injury and partial hepatectomy.四氯化碳损伤和部分肝切除术后大鼠甲胎蛋白产生增加的不同机制
Cancer Res. 1976 Jul;36(7 PT 1):2171-5.
3
Dissociation of alpha-macrofetoprotein and alpha-fetoprotein production during experimental injury.实验性损伤期间α-巨胎蛋白与甲胎蛋白生成的分离
Lab Invest. 1979 Feb;40(2):134-9.
4
alpha-Fetoprotein content in liver from rats following hepatotoxin administration and partial hepatectomy.给予肝毒素并进行部分肝切除术后大鼠肝脏中的甲胎蛋白含量
Acta Hepatogastroenterol (Stuttg). 1978 Jun;25(3):189-92.
5
Catabolism of alpha-fetoprotein in carbon tetrachloride-injured rats.四氯化碳损伤大鼠中甲胎蛋白的分解代谢
Acta Hepatogastroenterol (Stuttg). 1977 Aug;24(4):238-40.
6
Regulatory mechanisms of alpha-fetoprotein production in injured rat liver.大鼠肝脏损伤时甲胎蛋白产生的调节机制
Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):102-5.
7
Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.多种肝毒素诱导的大鼠肝损伤中α1-甲胎蛋白生成增加。
Gan. 1976 Apr;67(2):279-87.
8
Prompt elevation of rat serum alpha-fetoprotein by acute liver injury following a single injection of ethionine.单次注射乙硫氨酸后急性肝损伤导致大鼠血清甲胎蛋白迅速升高。
Int J Cancer. 1976 Apr 15;17(4):518-24. doi: 10.1002/ijc.2910170415.
9
[Synthesis and localization of alpha fetoprotein in liver regeneration in mice].[小鼠肝脏再生中甲胎蛋白的合成与定位]
Biull Eksp Biol Med. 1976 Oct;82(10):1251-4.
10
[Atypical alpha fetoprotein-synthesizing cells in the regenerating mouse liver].[再生小鼠肝脏中的非典型甲胎蛋白合成细胞]
Biull Eksp Biol Med. 1982 Jul;94(7):82-4.

引用本文的文献

1
Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.蛋氨酸类似物乙硫氨酸在体内和体外作用的分子层面研究
Microbiol Rev. 1982 Sep;46(3):281-95. doi: 10.1128/mr.46.3.281-295.1982.