Vignais L, Nait Oumesmar B, Baron-Van Evercooren A B
INSERM U 134, Hôpital de la Salpêtrière, Paris, France.
Neuroreport. 1995 Oct 23;6(15):1993-6. doi: 10.1097/00001756-199510010-00010.
The platelet-derived growth factors (PDGF) are constitutively expressed by neurones in the central nervous system (CNS). The synthesis of the PDGF-alpha-receptor (PDGF-alpha R) is commonly attributed to oligodendrocyte precursors during late embryonic and early postnatal development, suggesting communication between neurones and glia which orchestrates amplification and final targeting of the myelinating cells. However PDGF A production persists when central myelination is achieved, which suggests that PDGF-alpha R are present in the adult CNS. In this study, we demonstrate the production of PDGF-alpha R transcripts and protein by various neuronal populations of the adult CNS. We propose a developmental shift, where glial cells and neurones are consecutive targets of PDGF A and neuromodulatory effects of PDGF, exerted on mature neurones via the expression of the PDGF-alpha R.
血小板衍生生长因子（PDGF）在中枢神经系统（CNS）中由神经元组成性表达。在胚胎后期和出生后早期发育过程中，PDGF-α受体（PDGF-αR）的合成通常归因于少突胶质细胞前体，这表明神经元与神经胶质细胞之间存在通讯，这种通讯协调了髓鞘形成细胞的扩增和最终靶向。然而，当实现中枢髓鞘形成时，PDGF A的产生持续存在，这表明PDGF-αR存在于成体CNS中。在本研究中，我们证明了成体CNS的各种神经元群体产生PDGF-αR转录本和蛋白质。我们提出了一种发育转变，即神经胶质细胞和神经元是PDGF A的连续靶标，并且PDGF通过PDGF-αR的表达对成熟神经元产生神经调节作用。
