Currie D, Hashemi K, Fothergill J, Findlay A, Harris A, Hindmarch I
Human Psychopharmacology Research Unit, University of Surrey, Milford Hospital, Godalming, UK.
Occup Med (Lond). 1995 Dec;45(6):323-5. doi: 10.1093/occmed/45.6.323.
The objective of this study was to determine whether there is a greater incidence of psychotropic drugs in the blood of those 'responsible' for an accident compared with those not 'responsible' for an accident. Blood samples were taken from people involved in accidents presenting at the accident and emergency departments of two teaching hospitals over a five-month period and analysed for the presence of alcohol, tricyclic anti-depressants (TCAs) and benzodiazepines (BZs). Details of the accident were used to produce a test group (accidents where a drug may have contributed) and a control group (accidents where the presence of a drug could not have been a factor). In total, 229 samples were collected. The only criterion for inclusion in the study was that the accident was of sufficient severity to merit the routine taking of a blood sample, in which case an additional amount was taken for the purposes of this investigation. In all, 63 samples (27.5%) were positive for at least one of alcohol, TCA or BZ. Of the accidents represented by these samples, 48 could have been caused by the presence of the drug (responsible group) and 15 could not (not responsible group). There was a significantly greater representation of TCAs and BZs in the blood taken from the responsible group compared with the not responsible group (P < 0.0045).
本研究的目的是确定与非事故“责任方”相比，事故“责任方”血液中精神药物的发生率是否更高。在五个月的时间里，从两家教学医院的事故与急诊科收治的事故相关人员中采集血样，分析其中酒精、三环类抗抑郁药（TCA）和苯二氮䓬类药物（BZ）的存在情况。利用事故细节划分出一个试验组（药物可能起作用的事故）和一个对照组（药物不可能成为事故因素的事故）。总共采集了229份样本。纳入本研究的唯一标准是事故严重程度足以值得常规采集血样，在此情况下，为本次调查额外采集一份血样。总体而言，63份样本（27.5%）至少对酒精、TCA或BZ中的一种呈阳性反应。在这些样本所代表的事故中，48起可能是由药物存在导致的（责任组），15起则不是（非责任组）。与非责任组相比，责任组血液中TCA和BZ的含量明显更高（P < 0.0045）。
