Edwards S, Paton D
Virology Department, Ministry of Agriculture, Fisheries, and Food, Central Veterinary Laboratory, Weybridge, United Kingdom.
Vet Clin North Am Food Anim Pract. 1995 Nov;11(3):563-77. doi: 10.1016/s0749-0720(15)30467-9.
Monoclonal antibody typing of pestiviruses, supplemented with genetic sequence comparisons, has shown that at least four antigenic clusters can be identified within the genus. One cluster represents "classic" bovine viral diarrhea strains, which also have been isolated occasionally from sheep and pigs, whereas a second group corresponds to classic swine fever (hog cholera) strains. A distinct group of "true" border disease isolates is found in sheep and has been isolated occasionally from swine. The fourth group is antigenically quite distinct form the others and has been isolated from sheep, pigs, and cattle. It includes recent American isolates from cases of acute severe hemorrhagic disease. The implications of these findings for diagnosis and control are discussed.
瘟病毒的单克隆抗体分型，辅以基因序列比较，已表明在该属内至少可识别出四个抗原簇。一个簇代表“经典”牛病毒性腹泻毒株，这些毒株也偶尔从绵羊和猪中分离得到，而第二组对应经典猪瘟（猪霍乱）毒株。在绵羊中发现了一组独特的“真正”边界病分离株，偶尔也从猪中分离得到。第四组在抗原性上与其他组截然不同，已从绵羊、猪和牛中分离得到。它包括近期美国从急性严重出血病病例中分离出的毒株。讨论了这些发现对诊断和控制的意义。
