Sölder B, Allerberger F, Covi B, Maurer K, Scheminzky C, Kreczy A, Schön G, Dierich M P
Klinik für Kinder- und Jugendheilkunde, Universität Innsbruck.
Immun Infekt. 1995 Dec;23(6):228-31.
Bartonella henselae is an etiologic agent of cat-scratch disease and, in immunocompromised patients, of bacillary angiomatosis and other severe syndromes. Cat-scratch disease usually presents as lymphadenopathy, which resolves spontaneously within 2-4 months. The utility of antibiotic therapy remains controversial. In Tyrol four cases of human cat-scratch disease were diagnosed in children in 1994, yielding a prevalence of 0.7/100,000 per year. A 3-year-old boy had lymphadenitis coli since one year despite antituberculosis therapy which was initiated because of the histopathological picture and a positive tuberculin reaction (despite negative mycobacteria-cultures and -PCR). Two girls, age 9 and 13 years, had lymphadenitis at upper or lower extremities after cat-scratches from kittens. A 13-year-old boy presented with febrile illness and right hip pain, computer tomography revealed an osteolytic lesion; symptoms subsided within 3 weeks. Diagnosis of cat-scratch disease is based on cat contact, negative studies for other similar diseases, characteristic histopathologic features (if available), and results of an indirect immunofluorescence test (antigen: Houston-1 isolate, ATCC 49882). We believe that the availability of this serological test will increase the number of diagnosed cases of human Bartonella henselae infections.
汉赛巴尔通体是猫抓病的病原体，在免疫功能低下的患者中，也是杆菌性血管瘤病和其他严重综合征的病原体。猫抓病通常表现为淋巴结病，可在2 - 4个月内自行消退。抗生素治疗的效用仍存在争议。1994年在蒂罗尔州，4例儿童人类猫抓病被确诊，年患病率为0.7/10万。一名3岁男孩因组织病理学表现和结核菌素反应阳性（尽管分枝杆菌培养和聚合酶链反应均为阴性）而接受抗结核治疗，但一年来一直患有结肠淋巴结炎。两名女孩，分别为9岁和13岁，被小猫抓伤后上肢或下肢出现淋巴结炎。一名13岁男孩出现发热性疾病和右髋疼痛，计算机断层扫描显示有溶骨性病变；症状在3周内消退。猫抓病的诊断基于与猫的接触史、对其他类似疾病的检查结果为阴性、特征性组织病理学特征（如有）以及间接免疫荧光试验结果（抗原：休斯顿-1分离株，ATCC 49882）。我们认为，这种血清学检测方法的应用将增加人类汉赛巴尔通体感染的确诊病例数。
