Quintarelli G, Vocaturo A, Zito R, Rodén L
Experientia. 1977 Mar 15;33(3):298-9. doi: 10.1007/BF02002789.
Proteoglycans in cartilage are found as aggregates and as monomers. Evidence has been obtained indicating that hyaluronic acid, normally present in this tissue, binds together monomers into large molecular weight aggregates. In this investigation, the interacting region of the protein backbone has been studied. The results unequivocally demonstrated that the epsilon amino groups of lysine are involved in hyaluronic acid binding to proteoglycans and that their blocking by acetylation either prevents reaggregation or disaggregates the high mol.w aggregates.
软骨中的蛋白聚糖以聚集体和单体形式存在。已有证据表明，正常存在于该组织中的透明质酸可将单体结合成大分子聚集体。在本研究中，对蛋白质主链的相互作用区域进行了研究。结果明确表明，赖氨酸的ε氨基参与透明质酸与蛋白聚糖的结合，并且通过乙酰化对其进行封闭可阻止重新聚集或使高分子量聚集体解聚。
