Theegarten D, Philippou S, Zaboura G
Abteilung für Pathologie, Ruhr-Universität Bochum.
Pneumologie. 1995 Dec;49(12):674-7.
This is a report on 5 cases of mediastinal germ cell tumours. Of three mature teratomas seen in a 48-year old male and a 21-year old and 19-year old female, one was asymptomatic, another one associated with streptococcal pneumonia and the third associated with progressive cough irritation. In addition, a seminoma was seen in a male of 58 years of age and a yolk sac tumour (mesonephroma type 2) in a male of 23 years. Whereas in mature teratomas surgical resection can be considered sufficient, resection combined with chemotherapy should be performed in patients suffering from malignant germ cell tumours, and in addition also radiotherapy in case of seminoma. This approach may result in a significant improvement of the prognosis in malignant mediastinal germ cell tumours.
这是一篇关于5例纵隔生殖细胞肿瘤的报告。在一名48岁男性以及一名21岁和19岁女性中发现了3例成熟畸胎瘤，其中1例无症状，另1例与链球菌肺炎相关，第3例与进行性咳嗽刺激相关。此外，在一名58岁男性中发现了1例精原细胞瘤，在一名23岁男性中发现了1例卵黄囊瘤（中肾瘤2型）。对于成熟畸胎瘤，手术切除可被认为足够，但对于恶性生殖细胞肿瘤患者，应进行手术切除并联合化疗，对于精原细胞瘤患者还应进行放疗。这种方法可能会显著改善恶性纵隔生殖细胞肿瘤的预后。
