Yoshida H, Yoshimasu F
Department of Neuropsychiatry, Wakayama Medical College.
Nihon Rinsho. 1996 Jan;54(1):111-6.
The etiology of Alzheimer's disease (AD) still remains unknown in spite of intensive research efforts. Recent genetic linkage studies have been reported regarding some candidate genes for familial Alzheimer's disease, such as amyloid precursor protein (APP) gene and apolipoprotein E gene. On the other hand, several risk factors of AD have been revealed by epidemiological studies, including age, family history, head trauma, thyroid dysfunctions and aluminum (Al). Our study of bulk sample analysis in AD brain using neutron activation analysis showed a significant increase of Al and iron (Fe) concentrations, especially in the cerebral cortices compared with age-matched controls. Based on these results, the possible role of trace elements on the etiopathogenesis of AD is discussed.
尽管进行了大量深入研究，但阿尔茨海默病（AD）的病因仍然不明。最近有关于家族性阿尔茨海默病一些候选基因的遗传连锁研究报道，比如淀粉样前体蛋白（APP）基因和载脂蛋白E基因。另一方面，流行病学研究揭示了AD的若干风险因素，包括年龄、家族史、头部外伤、甲状腺功能障碍和铝（Al）。我们利用中子活化分析对AD脑进行大量样本分析的研究表明，与年龄匹配的对照组相比，Al和铁（Fe）浓度显著升高，尤其是在大脑皮层。基于这些结果，讨论了微量元素在AD发病机制中的可能作用。
