Vance D E, Ehmann W D, Markesbery W R
Department of Chemistry, University of Kentucky, Lexington 40506.
Neurotoxicology. 1988 Summer;9(2):197-208.
The concentrations of 17 elements in the hair and nails of 180 Alzheimer's disease (AD) and control subjects have been determined by instrumental neutron activation analysis (INAA). Comparisons of trace element levels of properly matched AD and control groups revealed significant imbalances in the concentrations of six elements (Br, Ca, Co, Hg, K, and Zn) between disease and control groups. It is noteworthy that each of these has previously been shown by our group, or others, to be altered in some AD brain region(s). Geometric means for each element in both hair and nails of AD and control subjects are presented, and significant differences noted. The significance of these alterations with regard to the possible role of trace elements in the etiology of AD is discussed.
通过仪器中子活化分析（INAA）测定了180名阿尔茨海默病（AD）患者和对照者头发和指甲中17种元素的浓度。对匹配良好的AD组和对照组的微量元素水平进行比较后发现，疾病组和对照组之间六种元素（溴、钙、钴、汞、钾和锌）的浓度存在显著失衡。值得注意的是，我们小组或其他研究小组之前已证明，这些元素中的每一种在某些AD脑区都发生了变化。列出了AD患者和对照者头发和指甲中每种元素的几何平均值，并指出了显著差异。讨论了这些变化对于微量元素在AD病因学中可能作用的意义。
