Thompson C M, Markesbery W R, Ehmann W D, Mao Y X, Vance D E
Department of Chemistry, University of Kentucky, Lexington 40506.
Neurotoxicology. 1988 Spring;9(1):1-7.
Alzheimer's disease (AD) brain trace-element imbalances in the amygdala, hippocampus and nucleus basalis of Meynert (nbM) are found in most cases to be consistent with those previously reported in samples derived principally from AD cerebral cortex (Ehmann et al., 1986). The elevation of mercury in AD nbM, as compared to age-matched controls, is the largest trace-element imbalance observed to date in AD brain. In addition to the general confirmation of imbalances for Cs, Hg, N, Na, P, and Rb noted previously in cerebral cortex samples, imbalances for Fe, K, Sc, and Zn were observed in two regions and one region also exhibited imbalances for both Co and Se. Persistent imbalances for the univalent cations Na, K, Rb and Cs support arguments for a membrane abnormality in AD. The data presented here also provide the first comprehensive simultaneous multi-element determinations in both control and AD nbM.
在大多数情况下，阿尔茨海默病（AD）患者大脑杏仁核、海马体和迈内特基底核（nbM）中的微量元素失衡情况，与先前主要从AD大脑皮质样本中报告的情况一致（埃曼等人，1986年）。与年龄匹配的对照组相比，AD患者nbM中汞含量的升高是迄今为止在AD大脑中观察到的最大的微量元素失衡。除了先前在大脑皮质样本中发现的铯、汞、氮、钠、磷和铷失衡得到普遍证实外，在两个区域还观察到铁、钾、钪和锌的失衡，并且在一个区域还发现钴和硒均存在失衡。单价阳离子钠、钾、铷和铯的持续失衡支持了AD存在膜异常的观点。本文提供的数据也是首次对对照和AD患者的nbM进行全面的同时多元素测定。
