Schwartz S E, Levine R A, Singh A, Scheidecker J R, Track N S
Gastroenterology. 1982 Oct;83(4):812-7.
The effects of sustained fiber ingestion on gastric emptying glucose tolerance, hormone responses, and jejunal absorption of glucose and lysine were studied in healthy volunteers. Subjects were placed on a low-fiber (3 g) diet for 2 wk, followed by 4 wk of an isocaloric diet supplemented with 20 g/day of either apple pectin (7 subjects) or alpha-cellulose (6 subjects). At the conclusion of each dietary period subjects ingested a low-fiber breakfast surface-labeled with 99mtechnetium sulfur-colloid. Gastric emptying half-time, plasma glucose, calcium, phosphorus, insulin, glucagon, gastrin, human pancreatic polypeptide, and motilin were determined. Gastric emptying half-time was prolonged approximately twofold after pectin supplementation (p less than 0.005) and returned to normal 3 wk after discontinuing pectin supplementation. Cellulose supplementation did not alter the gastric emptying rate. Plasma glucose, calcium, phosphorus, and hormonal responses to the meal were unchanged after either pectin or cellulose supplementation. Pectin ingestion did not impair intestinal absorption of glucose or lysine. In contrast to sustained cellulose ingestion, sustained pectin ingestion slows the gastric emptying rate; the mechanism underlying this adaptive effect is unknown.
在健康志愿者中研究了持续摄入纤维对胃排空、葡萄糖耐量、激素反应以及空肠葡萄糖和赖氨酸吸收的影响。受试者先接受为期2周的低纤维（3克）饮食，随后是4周的等热量饮食，其中一组（7名受试者）每天补充20克苹果果胶，另一组（6名受试者）每天补充20克α-纤维素。在每个饮食阶段结束时，受试者摄入一顿用99m锝硫胶体进行表面标记的低纤维早餐。测定胃排空半衰期、血浆葡萄糖、钙、磷、胰岛素、胰高血糖素、胃泌素、人胰多肽和胃动素。补充果胶后胃排空半衰期延长约两倍（p<0.005），停止补充果胶3周后恢复正常。补充纤维素未改变胃排空率。补充果胶或纤维素后，血浆葡萄糖、钙、磷以及对该餐的激素反应均未改变。摄入果胶不会损害葡萄糖或赖氨酸的肠道吸收。与持续摄入纤维素不同，持续摄入果胶会减慢胃排空率；这种适应性效应的潜在机制尚不清楚。
