Tsujii H
Nihon Rinsho. 1996 Jan;54(1):268-73.
Introduction of heavy charged particles (protons and heavy-ions) is a promising approach in cancer treatment, permitting selective irradiation to the tumor while minimizing irradiation to the surrounding normal tissues. Additionally, the efficiency of heavy-ions will be further augmented by an increased biological effectiveness caused by high-LET components. At the University of Tsukuba, treatment with 250 MeV proton beams is being performed and, unlike other facilities in the world, successful results have been obtained in the thoraco-abdominal and pelvic tumors. Heavy-ion therapy was initiated at the University of California, and in 1993 the first heavy-ion synchrotron complex dedicated to medical use in a hospital environment was completed at the National Institute of Radiological Sciences. The carbon-ion therapy was begun in June 1994 which is expected to provide optimal results in various type of tumors. A construction of heavy-ion facility is also under consideration in Germany (GSI), Austria (AUSTRON), Italy (TERA) and Japan (Hyogo prefecture).
引入重带电粒子（质子和重离子）是一种很有前景的癌症治疗方法，它能够在对周围正常组织的辐射最小化的同时，对肿瘤进行选择性照射。此外，高传能线密度成分所导致的生物有效性增加，将进一步提高重离子的治疗效果。在筑波大学，正在开展250兆电子伏特质子束治疗，与世界上其他机构不同的是，在胸腹部和盆腔肿瘤的治疗中已取得了成功的结果。重离子治疗始于加利福尼亚大学，1993年，第一座专门用于医院环境下医疗用途的重离子同步加速器在日本国立放射科学研究所建成。碳离子治疗于1994年6月开始，有望在各类肿瘤的治疗中取得最佳效果。德国（GSI）、奥地利（AUSTRON）、意大利（TERA）和日本（兵库县）也在考虑建设重离子治疗设施。
