Kovács A M, Telegdy G
Department of Pathophysiology, A. Szent-Györgyi Medical University, Szeged, Hungary.
Physiol Behav. 1996 Jul;60(1):183-6. doi: 10.1016/0031-9384(95)02254-6.
The effects of administration of amylin into the lateral brain ventricle on active and passive avoidance behavior and open field activity were studied in rats. Amylin increased the latency of passive avoidance behavior in a dose-dependent manner between 250 ng and 1 microgram, but 50 and 100 ng and 2 micrograms were ineffective when given immediately after passive avoidance conditioning. As concerns active avoidance behavior, the extinction was facilitated in a dose-dependent manner. The locomotion in an open field was inhibited at 3 h at 500 ng and 1 microgram doses and at 6 h at 250 and 500 ng and 1 microgram doses. However, the action was still present 24 h after administration of a large dose (1 microgram). The rearing activity was increased 3 and 6 h after administration of 1 microgram. Smaller doses (50, 100, 250, and 500 ng) were ineffective. Twenty-four hours following administration, none of the doses used exhibited any effect. The grooming activity was increased 3, 6, and 24 h after administration of 1 microgram amylin. Other doses were ineffective. The results suggest that amylin influences the behavioral reaction in these paradigms mainly by acting on locomotion, and not by modifying learning and memory processes.
研究了向大鼠侧脑室注射胰淀素对主动和被动回避行为以及旷场活动的影响。胰淀素在250纳克至1微克之间以剂量依赖性方式增加被动回避行为的潜伏期，但在被动回避条件反射后立即给予50纳克、100纳克和2微克时无效。关于主动回避行为，消退以剂量依赖性方式得到促进。在500纳克和1微克剂量时，3小时后旷场中的运动受到抑制；在250纳克、500纳克和1微克剂量时，6小时后运动受到抑制。然而，在给予大剂量（1微克）后24小时，这种作用仍然存在。给予1微克后3小时和6小时，竖毛活动增加。较小剂量（50纳克、100纳克、250纳克和500纳克）无效。给药24小时后，所用剂量均未显示出任何效果。给予1微克胰淀素后3小时、6小时和24小时，理毛活动增加。其他剂量无效。结果表明，胰淀素在这些范式中主要通过作用于运动来影响行为反应，而不是通过改变学习和记忆过程。
