Vernigora A N, Gengin M T, Saldaev D A
Penza State Pedagogical University.
Ukr Biokhim Zh (1999). 2000 Jan-Feb;72(1):106-8.
Effects of single intraperitoneal administration of testosterone propionate (3 or 30 mg/kg body weight) on activity of carboxypeptidase H in pituitary body and hypothalamus of female white mouse were studied. It was found that testosterone propionate treatment (3 and 30 mg/kg body weight) increased the carboxypeptidase H activity in pituitary through 0.5 hour and it decreased one in 24 hours after treatment. The carboxypeptidase H activity in hypothalamus was lower as compared with control animals in 24 hours after testosterone propionate treatment in the dose 3 mg/kg body weight. However, the carboxypeptidase H activity in hypothalamus was lower in 0.5 and 24 hours and it was higher in 4 h after testosterone propionate treatment in the dose 30 mg/kg body weight as compared with the control. These data suggest that testosterone affects the carboxypeptidase H activity by changing the level of enzyme gene expression.
研究了单次腹腔注射丙酸睾酮（3或30毫克/千克体重）对雌性小白鼠垂体和下丘脑羧肽酶H活性的影响。结果发现，丙酸睾酮处理（3和30毫克/千克体重）使垂体中的羧肽酶H活性在处理后0.5小时升高，而在处理后24小时降低。在剂量为3毫克/千克体重的丙酸睾酮处理后24小时，下丘脑的羧肽酶H活性低于对照动物。然而，在剂量为30毫克/千克体重的丙酸睾酮处理后，下丘脑的羧肽酶H活性在0.5小时和24小时较低，而在4小时时高于对照。这些数据表明，睾酮通过改变酶基因表达水平来影响羧肽酶H活性。
