McCurdy S A, Pocekay D, Hammond S K, Woskie S R, Samuels S J, Schenker M B
Department of Internal Medicine, School of Medicine, University of California, Davis 95616-8638, USA.
Am J Ind Med. 1995 Dec;28(6):847-60. doi: 10.1002/ajim.4700280616.
As part of the Semiconductor Health Study, we performed a cross-sectional survey to assess prevalence of specific nonreproductive health outcomes and their association with occupational exposures. A total of 3,175 persons from eight manufacturing sites across the U.S. completed a health and work questionnaire (78% participation rate). After adjusting for confounders, responses from fabrication room (fab) workers indicated a greater risk than those of nonfab workers for upper respiratory symptoms (relative risk [RR] = 1.08; 95% confidence interval [CI] = 1.03-1.13); a dose-response effect with hours per day spent in fabs was observed. Fab workers also had greater prevalence for persistent wheezing (RR = 1.82; 95% CI = 1.15-2.87), dermatitis within the past year (RR = 1.19; 95% CI = 1.04-1.35), and alopecia (RR = 1.73; 95% CI = 1.16-2.54). Female sex, a somatization index score, and smoking were important nonoccupational covariates. Increased respiratory symptoms may result from occupational exposures in fabs; further research is needed to identify causal agents and develop prevention strategies.
作为半导体健康研究的一部分，我们开展了一项横断面调查，以评估特定非生殖健康结果的患病率及其与职业暴露的关联。来自美国八个制造场所的总共3175人完成了一份健康与工作问卷（参与率为78%）。在对混杂因素进行调整后，来自制造车间（fab）工人的回答表明，与非fab工人相比，他们出现上呼吸道症状的风险更高（相对风险[RR]=1.08；95%置信区间[CI]=1.03 - 1.13）；观察到每天在fab中度过的小时数存在剂量反应效应。Fab工人持续性喘息的患病率也更高（RR = 1.82；95% CI = 1.15 - 2.87），过去一年患皮炎的患病率更高（RR = 1.19；95% CI = 1.04 - 1.35），以及脱发的患病率更高（RR = 1.73；95% CI = 1.16 - 2.54）。女性、躯体化指数得分和吸烟是重要的非职业协变量。fab中的职业暴露可能导致呼吸道症状增加；需要进一步研究以确定致病因素并制定预防策略。
