Eskenazi B, Gold E B, Lasley B L, Samuels S J, Hammond S K, Wight S, O'Neill Rasor M, Hines C J, Schenker M B
Maternal and Child Health and Epidemiology Programs, School of Public Health, University of California, Berkeley 94720, USA.
Am J Ind Med. 1995 Dec;28(6):833-46. doi: 10.1002/ajim.4700280615.
Women who work in silicon wafer fabrication rooms (fabs) have been reported to have an increased risk of spontaneous abortion (SAB). Although previous studies have included only clinically recognized SABs, more than two-thirds of SABs may be clinically unrecognized. To determine whether fab work is associated with SAB, we recruited 152 fab and 251 nonfab workers, who collected urine samples for a 6-month period. Samples were analyzed by immunoradiometric assay for the presence of human chorionic gonadotropin to detect early fetal losses. Approximately 63% of fab and 46% of nonfab pregnancies ended in SAB [adjusted relative risk (RR) = 1.25; 95% confidence interval (CI) = 0.63-1.76]. Similar RR were seen for women who worked in dopant and thin-film processes (adjusted RR = 1.30; 95% CI = 0.51-1.96) or in masking (adjusted RR = 1.30; 95% CI = 0.59-1.84). The four pregnancies among women who worked with ethylene-based glycol ethers ended in SAB.
据报道，在硅晶圆制造车间（晶圆厂）工作的女性自然流产（SAB）风险增加。尽管先前的研究仅纳入了临床确诊的SAB，但超过三分之二的SAB可能未被临床识别。为了确定在晶圆厂工作是否与SAB有关，我们招募了152名晶圆厂工人和251名非晶圆厂工人，他们在6个月的时间里收集尿液样本。通过免疫放射分析检测样本中是否存在人绒毛膜促性腺激素，以检测早期胎儿丢失情况。晶圆厂约63%的妊娠和非晶圆厂约46%的妊娠以SAB告终[校正相对风险（RR）=1.25；95%置信区间（CI）=0.63 - 1.76]。在从事掺杂和薄膜工艺工作的女性中（校正RR = 1.30；95% CI = 0.51 - 1.96）或从事掩膜工作的女性中（校正RR = 1.30；95% CI = 0.59 - 1.84）也观察到了类似的RR。使用基于乙二醇醚的女性中的四次妊娠均以SAB告终。
