Samuels S J, McCurdy S A, Pocekay D, Hammond S K, Missell L, Schenker M B
Department of Internal Medicine, School of Medicine, University of California, Davis 95616-8638, USA.
Am J Ind Med. 1995 Dec;28(6):873-82. doi: 10.1002/ajim.4700280618.
Fertility among men working in semiconductor manufacturing during 1984-89 was assessed in a 1990-91 cross-sectional study of eight companies. Men working in wafer fabrication rooms (fabs) (n = 241, 165 births) were compared to men in nonfabrication (nonfab) jobs (n = 447, 300 births). Results showed that 17% of fab men and 14% of nonfab men reported ever trying for > or = 1 year to conceive [relative risk (RR) = 1.21, 95% confidence interval (CI) = 0.83-1.74]. Crude birth rates (births/1,000 person months) were similar [15 fab, 17 nonfab; crude fertility ratio (FR) = 1.09, 95% CI = 0.86-1.36], as were birth rates adjusted by Cox models for confounders (adjusted FR = 0.98, 95% CI = 0.80-1.19, p = 0.79). Fab men who worked in furnace, thin-film, or ion implantation areas were more likely than nonfab men to report previous difficulty conceiving (25%, RR = 1.79, 95% CI = 1.09-2.94), and their past fertility was lower (nine births/1,000 person months; crude FR = 0.66, 95% CI = 0.40-1.02; adjusted FR = 0.73, 95% CI = 0.50-1.09, p = 0.12). Problems included lack of contraception data and misclassification of fab subgroups.
在1990 - 1991年对八家公司进行的一项横断面研究中，评估了1984 - 1989年期间从事半导体制造工作的男性的生育能力。将在晶圆制造车间（晶圆厂）工作的男性（n = 241，165例生育）与从事非制造（非晶圆厂）工作的男性（n = 447，300例生育）进行比较。结果显示，17%的晶圆厂男性和14%的非晶圆厂男性报告曾尝试怀孕≥1年[相对风险（RR）= 1.21，95%置信区间（CI）= 0.83 - 1.74]。粗出生率（每1000人月的生育数）相似[晶圆厂为15，非晶圆厂为17；粗生育比（FR）= 1.09，95% CI = 0.86 - 1.36]，经Cox模型对混杂因素进行调整后的出生率也相似（调整后的FR = 0.98，95% CI = 0.80 - 1.19，p = 0.79）。在熔炉、薄膜或离子注入区域工作的晶圆厂男性比非晶圆厂男性更有可能报告以前有受孕困难（25%，RR = 1.79，95% CI = 1.09 - 2.94），且他们过去的生育能力较低（每1000人月9例生育；粗FR = 0.66，95% CI = 0.40 - 1.02；调整后的FR = 0.73，95% CI = 0.50 - 1.09，p = 0.12）。问题包括缺乏避孕数据以及晶圆厂亚组的错误分类。
