Schenker M B, Gold E B, Beaumont J J, Eskenazi B, Hammond S K, Lasley B L, McCurdy S A, Samuels S J, Saiki C L, Swan S H
Department of Internal Medicine, School of Medicine, University of California, Davis 95616-8638, USA.
Am J Ind Med. 1995 Dec;28(6):639-59. doi: 10.1002/ajim.4700280603.
This study tested the hypothesis that fabrication room (fab) work in the silicon-based semiconductor industry is associated with an increased risk of spontaneous abortion (SAB). The study was conducted nationwide at 14 companies representing a spectrum of large to small manufacturers. A small increase in risk of SAB was observed among fab workers compared with nonfabrication room (nonfab) workers in two cohorts, historical (adjusted RR = 1.43, 95% confidence interval [CI] 0.95-2.09) and prospective (adjusted RR = 1.25, 95% CI = 0.63-1.76). Analysis of specific fab exposures in the historical cohort showed a consistent, dose-response association of SAB with photoresist and developer solvents, whose major component was ethylene-based glycol ethers. The consistency of our findings and the toxicological data for these agents suggest that this is a causal association. Independent associations of SAB with self-reported stress and with etching fluorides were observed and require further research. No significant decrease in fertility was observed among men or women working in fabs, but reduced fecundability was suggested for some women fab workers.
硅基半导体行业的制造车间（fab）工作与自然流产（SAB）风险增加有关。该研究在全国范围内对14家代表不同规模制造商的公司进行。在两个队列中，与非制造车间（nonfab）工人相比，制造车间工人的SAB风险略有增加，这两个队列分别是历史队列（调整后的相对危险度RR = 1.43，95%置信区间[CI] 0.95 - 2.09）和前瞻性队列（调整后的RR = 1.25，95% CI = 0.63 - 1.76）。对历史队列中特定的制造车间暴露因素进行分析发现，SAB与光刻胶和显影剂溶剂存在一致的剂量反应关联，其主要成分是乙二醇醚。我们研究结果的一致性以及这些物质的毒理学数据表明这是一种因果关联。还观察到SAB与自我报告的压力以及蚀刻氟化物之间存在独立关联，这需要进一步研究。在制造车间工作的男性或女性中未观察到生育能力显著下降，但部分女性制造车间工人的受孕能力有所降低。
