Nieuwenhuijsen M J, Gordon S, Harris J M, Tee R D, Venables K M, Newman Taylor A J
Division of Occupational/Environmental Medicine and Epidemiology, University of California at Davis 95616-6648, USA.
Ann Occup Hyg. 1995 Dec;39(6):819-25. doi: 10.1016/0003-4878(95)00042-9.
We describe how much of the variation in rat urinary aeroallergen (RUA) levels may be explained by differences in site and exposure group in research establishments and we identify task categories associated with high RUA levels. In this population 73% of the variability in RUA levels could be explained by exposure group, site and their interaction term. Exposure group alone explained the majority of the variation (69%). The task category associated with the highest RUA level was cleaning out, followed by indirect contact with rats and handling rats. The task categories associated with the lowest levels were slide production, post mortem and experiments. These results may help choose appropriate exposure measures for epidemiological studies in research establishments in the future and may help reduce the incidence of laboratory animal allergy.
我们描述了研究机构中大鼠尿气变应原（RUA）水平的差异能在多大程度上解释其变异性，并确定了与高RUA水平相关的任务类别。在这一人群中，RUA水平73%的变异性可由暴露组、场所及其交互项来解释。仅暴露组就解释了大部分变异（69%）。与最高RUA水平相关的任务类别是清理，其次是与大鼠的间接接触和处理大鼠。与最低水平相关的任务类别是玻片制作、尸检和实验。这些结果可能有助于未来为研究机构的流行病学研究选择合适的暴露测量方法，并可能有助于降低实验动物过敏的发生率。
