组蛋白序列数据库：高度保守的核蛋白序列汇编。
Histone Sequence Database: a compilation of highly-conserved nucleoprotein sequences.
作者信息
Baxevanis A D, Landsman D
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 1996 Jan 1;24(1):245-7. doi: 10.1093/nar/24.1.245.
Abstract
By searching the current protein sequence databases using sequences from human and chicken histones H1/H5, H2A, H2B, H3 and H4, a database of aligned histone protein sequences with statistically significant sequence similarity to the search sequence was constructed. In addition, a nucleotide sequence database of the corresponding coding regions for these proteins has been assembled. The region of each of the core histones containing the histone fold motif is identified in the protein alignments. The database contains >1300 protein and nucleotide sequences. All sequences and alignments in this database are available through the World Wide Web at http://www.ncbi.nlm.nih.gov/Baxevani/HISTO NES.
摘要
通过使用人类和鸡的组蛋白H1/H5、H2A、H2B、H3和H4的序列搜索当前的蛋白质序列数据库，构建了一个与搜索序列具有统计学显著序列相似性的比对组蛋白蛋白质序列数据库。此外，还组装了这些蛋白质相应编码区的核苷酸序列数据库。在蛋白质比对中确定了每个包含组蛋白折叠基序的核心组蛋白区域。该数据库包含超过1300个蛋白质和核苷酸序列。该数据库中的所有序列和比对可通过万维网在http://www.ncbi.nlm.nih.gov/Baxevani/HISTONES上获取。
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