Sandberg M A, Gaudio A R
Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
Retina. 1995;15(5):407-12. doi: 10.1097/00006982-199515050-00006.
To determine whether photostress recovery time varies with severity of disease in age-related macular degeneration.
Photostress recovery time, visual acuity, and foveal retinal pigment epithelial atrophy were evaluated for the fellow eyes of 133 patients with unilateral neovascular age-related macular degeneration. Recovery times were measured by a method that flashed letters on a computer screen in random order before and after a 10 second bleach.
Recovery times were delayed in 62% of the patients (including 47% of those with normal visual acuity), ranged up to 6 times the normal limit, and increased with advancing age (P < 0.0001). Photostress recovery time was inversely correlated with visual acuity (P < 0.0001) and longer in eyes with visible atrophy than in eyes without atrophy (P = 0.0007). Significant relationships between these two pairs of measures were also found after controlling for age.
These findings support previous evidence that the time for visual recovery after exposure to a glare source is commonly slowed in age-related macular degeneration even among patients with normal visual acuity and further show that it can vary with age and extent of disease.
确定光应激恢复时间是否随年龄相关性黄斑变性疾病的严重程度而变化。
对133例单侧新生血管性年龄相关性黄斑变性患者的健眼评估光应激恢复时间、视力和黄斑视网膜色素上皮萎缩情况。恢复时间通过在10秒漂白前后以随机顺序在电脑屏幕上闪现字母的方法进行测量。
62%的患者恢复时间延迟（包括47%视力正常的患者），最长可达正常上限的6倍，且随年龄增长而增加（P<0.0001）。光应激恢复时间与视力呈负相关（P<0.0001），有可见萎缩的眼睛比无萎缩的眼睛恢复时间更长（P = 0.0007）。在控制年龄后，这两对测量指标之间也发现了显著关系。
这些发现支持了先前的证据，即即使在视力正常的患者中，年龄相关性黄斑变性患者在暴露于眩光光源后的视觉恢复时间通常也会减慢，并且进一步表明它会随年龄和疾病程度而变化。
