Greenwood D C, Muir K R, Packham C J, Madeley R J
Department of Public Health Medicine and Epidemiology, University Hospital, Queen's Medical Centre, Nottingham.
J Epidemiol Community Health. 1995 Dec;49(6):583-7. doi: 10.1136/jech.49.6.583.
To examine the effect on mortality of stopping smoking after myocardial infarction and the psychosocial factors that influence the decision to stop.
Analysis of smokers in a large prospective study. Self completed questionnaires provided information on psychosocial factors.
Coronary care units at six English hospitals participating in a multicentre clinical trial.
These comprised consenting myocardial infarction survivors who had been identified as smokers and who completed questionnaires within seven days of infarct at six hospitals participating in the Anglo-Scandinavian study of early thrombolysis. The 532 patients identified have been followed for over five and a half years. The main outcome measure was five year all cause mortality.
Smokers who stopped within one month showed significantly reduced mortality compared with those who persisted, adjusting for other prognostic indicators (odds ratio 0.56, 95% confidence interval 0.33, 0.98). Overall, 74% stopped smoking. Being married, low life stress levels before infarct, and higher social class were associated with stopping smoking but the differentials were small. Of the clinical variables, a final diagnosis of definite myocardial infarction was associated with stopping smoking. All associations remained after multiple logistic regression.
Smoking cessation can halve the smokers' odds of dying after myocardial infarction and psychosocial factors play a small but important role in the important decision to stop smoking. Health professionals should continue to stress the importance of stopping smoking to all patients as there is little evidence to support specific directing of advice to relatively "stress or "socially isolated" groups.
探讨心肌梗死后戒烟对死亡率的影响以及影响戒烟决定的社会心理因素。
对一项大型前瞻性研究中的吸烟者进行分析。通过自我填写问卷获取社会心理因素信息。
参与一项多中心临床试验的六家英国医院的冠心病监护病房。
这些对象包括同意参与研究的心肌梗死幸存者,他们被确定为吸烟者,且在参与英-斯堪的纳维亚早期溶栓研究的六家医院中,于心肌梗死后七天内完成了问卷填写。已对这532名确定的患者进行了超过五年半的随访。主要结局指标是五年全因死亡率。
与持续吸烟者相比,在一个月内戒烟的吸烟者,在对其他预后指标进行调整后,死亡率显著降低(比值比0.56,95%置信区间0.33,0.98)。总体而言,74%的人戒烟。已婚、心肌梗死前生活压力水平低以及社会阶层较高与戒烟有关,但差异较小。在临床变量中,最终确诊为明确的心肌梗死与戒烟有关。经过多重逻辑回归分析后,所有关联仍然存在。
戒烟可使心肌梗死后吸烟者的死亡几率减半,社会心理因素在戒烟这一重要决定中虽作用较小但很重要。卫生专业人员应继续向所有患者强调戒烟的重要性,因为几乎没有证据支持针对相对“压力大”或“社会孤立”群体提供特定的建议指导。