Cassidy M J, Jankelson D, Becker M, Dunne T, Walzl G, Moosa M R
Renal Unit, Groote Schuur Hospital.
S Afr Med J. 1995 Oct;85(10):996-8.
The prevalence of antibodies against hepatitis C virus (HCV) was determined in 103 haemodialysis patients who attended two dialysis units in South Africa. With the use of a second-generation enzyme-linked immunosorbent assay (UBI HCV EIA, Organon Teknika, The Netherlands) and a 4-recombinant immunoblot assay (Chiron Corporation, USA), antibodies to HCV were found in 22 patients (21%). Statistically significant associations with anti-HCV carrier status were duration of dialysis (P = 0.0005) and number of blood transfusions received (P = 0.008). With stepwise logistic regression analysis it was not possible to separate the effects of HCV status associated with these two variables. A transient elevation in alanine aminotransferase (ALT) occurred in 8 of the 22 anti-HCV-positive patients, compared with 14 of the 81 anti-HCV-negative patients (P = 0.054). As yet, no patients have clinical evidence of ongoing liver disease or persistently elevated ALT levels. Of the 45 dialysis staff members tested, none was positive for anti-HCV.
在南非两个透析单位就诊的103例血液透析患者中测定了丙型肝炎病毒（HCV）抗体的流行情况。使用第二代酶联免疫吸附试验（UBI HCV EIA，Organon Teknika，荷兰）和4重组免疫印迹试验（Chiron Corporation，美国），在22例患者（21%）中发现了HCV抗体。与抗-HCV携带者状态有统计学显著关联的是透析时间（P = 0.0005）和接受输血的次数（P = 0.008）。通过逐步逻辑回归分析，无法区分与这两个变量相关的HCV状态的影响。22例抗-HCV阳性患者中有8例出现丙氨酸转氨酶（ALT）短暂升高，而81例抗-HCV阴性患者中有14例出现ALT短暂升高（P = 0.054）。目前，尚无患者有持续性肝病的临床证据或ALT水平持续升高。在接受检测的45名透析工作人员中，没有抗-HCV阳性者。
