Paterson W G, Beck I T, Wang H
Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
Dig Dis Sci. 1996 Feb;41(2):357-64. doi: 10.1007/BF02093829.
Ambulatory esophageal manometry/pH-metry has been used primarily in patients with chest pain of presumed esophageal origin, and it is unclear whether the discriminating power of this test applies to other esophageal symptoms. In the present study, prolonged ambulatory manometry/pH recordings were compared in 17 healthy controls, 12 patients with atypical chest pain, and 11 patients with chest pain and nonstructural dysphagia using the Synectics microdigitrapper system. Chest pain patients tended to have higher values for all the pH variables, but their esophageal motility parameters were no different than controls. On the other hand, the chest pain plus dysphagia group was characterized by a significantly lower proportion of propagated contractions between 10 and 5 cm above the lower esophageal sphincter. This group also tended to have a higher frequency of high-amplitude or prolonged-duration contractions. In comparison to the results of standard stationary esophageal manometry, the prolonged ambulatory recordings were more sensitive in detecting esophageal motor dysfunction in the two patient groups. This study suggests that quantitative analysis of ambulatory pH/motility recordings is a sensitive method of evaluating patients with suspected esophageal dysfunction.
动态食管测压/酸碱度测定主要用于患有推测为食管源性胸痛的患者，而该检查的鉴别能力是否适用于其他食管症状尚不清楚。在本研究中，使用Synectics微型数字记录系统，对17名健康对照者、12名非典型胸痛患者和11名胸痛伴非器质性吞咽困难患者的长时间动态测压/酸碱度记录进行了比较。胸痛患者的所有酸碱度变量值往往较高，但其食管动力参数与对照组并无差异。另一方面，胸痛加吞咽困难组的特征是在下食管括约肌上方10至5厘米之间的推进性收缩比例显著降低。该组还往往有较高频率的高振幅或持续时间延长的收缩。与标准静态食管测压结果相比，长时间动态记录在检测两组患者的食管运动功能障碍方面更敏感。本研究表明，动态酸碱度/动力记录的定量分析是评估疑似食管功能障碍患者的一种敏感方法。
