Zea-Iriarte W L, Sekine I, Itsuno M, Makiyama K, Naito S, Nakayama T, Nishisawa-Takano J E, Hattori T
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Dig Dis Sci. 1996 Feb;41(2):377-86. doi: 10.1007/BF02093832.
One-hundred twelve hyperplastic polyps were analyzed. The aim was to study their malignant transformation. Among them, four hyperplastic polyps harbored adenocarcinoma; two were from our own institution (1.8%). The majority were pedunculated and located in the antrum with an average of 14.5 mm in diameter. The four polyps bore well-differentiated adenocarcinoma. Dysplasia and intestinal metaplasia were detected in two and three polyps, respectively. The cancer and dysplastic foci shared the same type of neutral and acid mucosubstances. p53 oncoprotein was positive in three cancer foci and in the dysplastic areas, and nucleolar organizer region counts were higher in the cancer foci. In conclusion, hyperplastic polyps have malignant potential. Such possibility increases in polyps larger than 14.5 mm. In our cases, the carcinoma foci may have arisen from dysplastic areas. Once the neoplastic changes occur, the cancer cells proliferate and behave as other adenocarcinomas of the stomach.
对112个增生性息肉进行了分析。目的是研究它们的恶变情况。其中，4个增生性息肉伴有腺癌；2个来自我们自己的机构（1.8%）。大多数息肉有蒂，位于胃窦部，平均直径为14.5毫米。这4个息肉均为高分化腺癌。分别在2个和3个息肉中检测到发育异常和肠化生。癌灶和发育异常灶具有相同类型的中性和酸性黏液物质。p53癌蛋白在3个癌灶和发育异常区域呈阳性，癌灶中的核仁组成区计数更高。总之，增生性息肉具有恶变潜能。息肉直径大于14.5毫米时，这种可能性会增加。在我们的病例中，癌灶可能起源于发育异常区域。一旦发生肿瘤性改变，癌细胞就会增殖，并表现为胃的其他腺癌。
