Kettering J D, Torabinejad M
Department of Microbiology and Molecular Genetics, Schools of Medicine and Dentistry, Loma Linda University, California 92350, USA.
J Endod. 1995 Nov;21(11):537-42. doi: 10.1016/S0099-2399(06)80980-5.
Little information is available regarding the mutagenicity of root-end filling materials. To study mutagenicity of Intermediate Restorative Material (IRM), Super-EBA, and a potential root-end filling material, mineral trioxide aggregate (MTA), strains of Salmonella typhimurium LT-2 (TA 98, R-factor strain and TA 1535, non-R-factor strains) were used in a standard Ames mutagenicity assay. Positive controls (S9 protein and benzo-(a)-pyrene and N-methyl-N'-nitro-N-nitrosoguanidine) operated properly. No increase in revertant bacteria colony counts occurred with any of the test materials. Based on these results, it seems that IRM, Super-EBA, and MTA are not mutagenic as measured by the Ames Test.
关于根充材料的致突变性，目前可得信息较少。为研究中间修复材料（IRM）、超强EBA以及一种潜在的根充材料——三氧化矿物凝聚体（MTA）的致突变性，在标准的艾姆斯致突变性试验中使用了鼠伤寒沙门氏菌LT-2菌株（TA 98，R因子菌株和TA 1535，非R因子菌株）。阳性对照（S9蛋白、苯并(a)芘和N-甲基-N'-硝基-N-亚硝基胍）运行正常。任何测试材料均未导致回复突变菌落计数增加。基于这些结果，通过艾姆斯试验测定，IRM、超强EBA和MTA似乎没有致突变性。
