Tissue reaction to implanted super-EBA and mineral trioxide aggregate in the mandible of guinea pigs: a preliminary report.

In vitro sealing ability and biocompatibility tests on mineral trioxide aggregate (MTA) have shown similar or better properties for this material than for existing root-end filling substances. The purpose of this study was to examine the tissue reaction of implanted Super-EBA and MTA in the mandibles of guinea pigs. After anesthetizing seven guinea pigs, raising a tissue flap and preparing two bony cavities, the test materials were placed in Teflon cups and implanted in the mandibles. Two bony cavities without implanted materials were left to heal and used as negative controls. The presence of inflammation, predominant cell type, and thickness of fibrous connective tissue adjacent to each implant was recorded. The tissue reaction to MTA implantation was slightly than that observed with Super-EBA implantation. Based on these results , it seems that both Super-EBA and MTA are biocompatible.