Sullivan J S, Morris C L, Richardson B B, Galland G G, Sullivan J J, Collins W E
Division of Parasitic Diseases, National Center for Infectious Diseases, Atlanta, Georgia 30333, USA.
J Parasitol. 1996 Apr;82(2):268-71.
Attempts were made to infect Aotus and Saimiri monkeys with sporozoites of 3 strains of Plasmodium knowlesi to determine the potential of these animals in a monkey/malaria model. Splenectomized Saimiri and Aotus monkeys were infected with the H strain of P. knowlesi via sporozoites from Anopheles dirus mosquitoes. Prepatent periods ranged from 5 to 16 days. Saimiri monkeys infected with the Philippine strain had prepatent periods ranging from 6 to 8 days. Saimiri monkeys infected with the Hackeri strain had prepatent periods ranging from 6 to 11 days. Exoerythrocytic (EE) stages of the Philippine strain were readily demonstrated; EE stages of the H strain were less abundant. Results indicate that the Philippine strain of P. knowlesi in Saimiri monkeys has a course of parasitemia and EE stages similar to those previously seen in macaques and could serve as a reproducible model for biologic and immunologic studies.
研究人员尝试用3株诺氏疟原虫的子孢子感染夜猴属和松鼠猴属猴子，以确定这些动物在猴/疟疾模型中的潜力。切除脾脏的松鼠猴属和夜猴属猴子通过大劣按蚊的子孢子感染诺氏疟原虫H株。潜隐期为5至16天。感染菲律宾株的松鼠猴属猴子潜隐期为6至8天。感染哈克里株的松鼠猴属猴子潜隐期为6至11天。菲律宾株的红细胞外期很容易被证实；H株的红细胞外期数量较少。结果表明，松鼠猴属猴子体内的菲律宾株诺氏疟原虫具有与之前猕猴体内所见相似的寄生虫血症病程和红细胞外期，可作为生物学和免疫学研究的可重复模型。
