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幽门螺杆菌在低pH值下产生离子梯度的能力与在强酸性条件下生长的细菌相似。

Capacity of Helicobacter pylori to generate ionic gradients at low pH is similar to that of bacteria which grow under strongly acidic conditions.

作者信息

Matin A, Zychlinsky E, Keyhan M, Sachs G

机构信息

Department of Microbiology and Immunology, School of Medicine, Stanford University, California, 94305.

出版信息

Infect Immun. 1996 Apr;64(4):1434-6. doi: 10.1128/iai.64.4.1434-1436.1996.

DOI:10.1128/iai.64.4.1434-1436.1996
PMID:8606113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173938/
Abstract

Helicobacter pylori colonized the highly acidic human gastric mucosa. At pH 3.0 to 7.0, this bacterium maintained a nearly neutral internal pH. Its membrane potential changed reciprocally with the pH gradient so that a relatively constant proton motive force was maintained. Possible, the capacity to maintain an appropriate transmembrane ionic gradient at a low pH contributes to the pathogenic propensities of this bacterium.

摘要

幽门螺杆菌定殖于高度酸性的人类胃黏膜中。在pH值为3.0至7.0的环境下，这种细菌能维持接近中性的内部pH值。其膜电位随pH梯度呈反向变化，从而维持相对恒定的质子动力势。维持低pH值下适当跨膜离子梯度的能力可能有助于该细菌的致病倾向。

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