Pettross C W, Appleman M D, Cohen H, Valenzuela J E, Chandrasoma P, Laine L A
Department of Pathology, LAC-USC Medical Center--USC School of Medicine 90033.
Dig Dis Sci. 1988 Jun;33(6):649-53. doi: 10.1007/BF01540425.
To determine the incidence and significance of Campylobacter pylori in patients undergoing routine endoscopic evaluation at this hospital, biopsies of the antrum were obtained from 132 patients and from 15 asymptomatic volunteers. Specimens were cultured and silver stained for the presence of C. pylori and were examined histologically. C. pylori was detected in 67 (51%) patients and two (13%) volunteers (P = 0.006). In patients, C. pylori was found significantly more often when the mucosa was inflamed (67%) than when the mucosa was normal (13%), and both volunteers with C. pylori had chronic gastritis on histological examination. When compared to the volunteers, patients with upper gastrointestinal symptoms had a significantly increased prevalence of antral inflammation, even if the endoscopic examination was normal. C. pylori is infrequently found in young asymptomatic adults but is found in both asymptomatic volunteers and patients in association with all forms of histological antral gastritis which is prevalent in patients with both normal endoscopic findings and peptic ulcer disease.
为确定本院接受常规内镜检查患者中幽门螺杆菌的发生率及意义，对132例患者和15名无症状志愿者进行胃窦活检。标本进行培养、银染色以检测幽门螺杆菌，并进行组织学检查。67例（51%）患者及2名（13%）志愿者检测到幽门螺杆菌（P = 0.006）。在患者中，黏膜发炎时幽门螺杆菌检出率（67%）显著高于黏膜正常时（13%），且两名携带幽门螺杆菌的志愿者组织学检查均有慢性胃炎。与志愿者相比，即使内镜检查正常，有上消化道症状的患者胃窦炎症发生率也显著增加。幽门螺杆菌在年轻无症状成年人中很少见，但在无症状志愿者和患者中均有发现，且与各种组织学类型的胃窦炎相关，胃窦炎在内镜检查正常及患有消化性溃疡病的患者中均很常见。
