Vandoolaeghe E, van Hunsel F, Nuyten D, Maes M
Clinical Research Center for Mental Health, AZ Stuivenberg, Antwerp, Belgium.
J Affect Disord. 1998 Mar;48(2-3):105-13. doi: 10.1016/s0165-0327(97)00165-1.
Some studies have shown disturbances in auditory event related potentials (AERPs) in patients with major depression.
In this exploratory study, the late AERP components, N100 (latency), P200 (amplitude and latency) and P300 (amplitude and latency) were recorded in 68 subjects, i.e. 39 major depressed subjects, with (n=4) or without (n=35) cognitive deterioration, 18 patients with Alzheimer's dementia (SDAT) and 11 normal volunteers. Twenty-five major depressed patients had repeated measurements of AERPs both before and after treatment with antidepressants.
Major depressed subjects without cognitive deterioration had significantly higher P300 latency and P200 amplitude than normal volunteers. SDAT patients and major depressed patients with cognitive impairment had a significantly higher P300 latency than depressed patients without cognitive impairment. In the latter, no significant alterations in any of the AERP components upon subchronic treatment with antidepressants were recorded. Nonresponders to antidepressant therapy had significantly higher pretreatment P300 latency and P200 amplitude than responders to treatment (P=0.006) and normal volunteers (P=0.0004).
The findings may suggest that delayed P300 latency as well as increased P200 amplitude accompany major depression and may predict a nonresponse to subsequent antidepressive therapy.
一些研究表明，重度抑郁症患者的听觉事件相关电位（AERP）存在紊乱。
在这项探索性研究中，对68名受试者记录了AERP的晚期成分，即N100（潜伏期）、P200（波幅和潜伏期）和P300（波幅和潜伏期），其中包括39名重度抑郁症患者，有（n = 4）或无（n = 35）认知功能减退，18名阿尔茨海默病性痴呆（SDAT）患者和11名正常志愿者。25名重度抑郁症患者在抗抑郁药治疗前后重复测量了AERP。
无认知功能减退的重度抑郁症患者的P300潜伏期和P200波幅显著高于正常志愿者。SDAT患者和有认知障碍的重度抑郁症患者的P300潜伏期显著高于无认知障碍的抑郁症患者。在后者中，亚慢性抗抑郁药治疗后，未记录到任何AERP成分有显著改变。抗抑郁治疗无反应者治疗前的P300潜伏期和P200波幅显著高于治疗有反应者（P = 0.006）和正常志愿者（P = 0.0004）。
这些发现可能提示，P300潜伏期延迟以及P200波幅增加与重度抑郁症相伴，并可能预示对后续抗抑郁治疗无反应。
